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Cheng-Jung Lai Selected Research

7- (4- (3- ethynylphenylamino)- 7- methoxyquinazolin- 6- yloxy)- N- hydroxyheptanamide

6/2013Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion.
5/2010CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity.
3/2010Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.

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Cheng-Jung Lai Research Topics

Disease

6Neoplasms (Cancer)
06/2013 - 06/2009
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2013 - 06/2009
1Stomach Neoplasms (Stomach Cancer)
06/2013
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/2009
1Colorectal Neoplasms (Colorectal Cancer)
06/2009
1Breast Neoplasms (Breast Cancer)
06/2009

Drug/Important Bio-Agent (IBA)

37- (4- (3- ethynylphenylamino)- 7- methoxyquinazolin- 6- yloxy)- N- hydroxyheptanamideIBA
06/2013 - 03/2010
2Histone Deacetylases (Histone Deacetylase)IBA
08/2012 - 05/2010
2ErbB Receptors (EGF Receptor)IBA
05/2010 - 12/2009
2Pharmaceutical PreparationsIBA
05/2010 - 06/2009
2Phosphotransferases (Kinase)IBA
05/2010 - 12/2009
2Erlotinib Hydrochloride (CP 358,774)FDA Link
12/2009 - 06/2009
2CUDC 305IBA
12/2009 - 06/2009
1Cadherins (E-Cadherin)IBA
06/2013
1Histone Deacetylase InhibitorsIBA
08/2012
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
08/2012
1CUDC-907IBA
08/2012
1human ERBB2 proteinIBA
05/2010
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
05/2010
1Heat-Shock Proteins (Heat-Shock Protein)IBA
12/2009
1tyrosine receptor (receptor, tyrosine)IBA
12/2009
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
06/2009

Therapy/Procedure

2Therapeutics
05/2010 - 06/2009